|
KMID : 1149220180260010013
|
|
Korean Journal of Oriental Medical Prescription
2018 Volume.26 No. 1 p.13 ~ p.26
|
|
|
The effect of prescriptions prepared by adding medicinal herbs(Rehmannia glutinosa Residue, Poria cocos Bark) and fermenting herbal materials based on formulas Iksuyoungjingo on immunological activity
|
|
Lee Yu-Mi
Kim Wang-In
Choi Dong-Hee
Kim Mi-Rae
Moon Yang-Seon
Kim Ji-Eun
Youn Dae-Hwan
Son Hong-Seok
Na Chang-Su
|
|
|
Abstract
|
|
|
Objectives : This study was carried out to enhance the activity of Iksuyoungjingo, which has the tonify Qi, nourish Yin effect of oriental medicine, and to study the effect of the prescriptions on the immunological activities.
Methods : Immunosuppression was induced by methotrexate (MTX) 2 mg / kg, the experimental group was divided into IYGgami-Ⅰ, IYGgami-Ⅰ-F, IYGgami-Ⅱ and IYGgami-Ⅱ-F groups. Each prescription was administered with drinking water for 20 days, and body weight was measured every 5 days during this period. Leukocyte, TNF-α, IL-2, IL-6, IgE, spleen weight and body weight were measured.
Results : In the changes of TNF-α, IL-2 and IL-6 as pro-inflammatory elements, all of the experimental groups showed a significant increase compared to the control group. In the IgE changes, the IYGgami-Ⅰ-F, IYGgami-Ⅱ and IYGgami-Ⅱ-F groups showed a significant decrease compared to the control group. In the changes of spleen weight, the IYGgami-Ⅱ-F group showed a significant increase compared to the control group. In the changes of WBC and lymphocytes, the IYGgami-Ⅰ-F group showed a significant increase compared to the control group.
Conclusions : From the above results, it can be observed that the efficacy against immunity is exerted in all of the preparations, and it was confirmed that the efficacy was maintained constant even when utilizing the Rehmannia glutinosa Residue and Poria cocos Bark, and that a more beneficial effect can be exerted in the effectiveness when the fermentation is carried out.
|
|
|
KEYWORD
|
|
|
immunological activities , Iksuyoungjingo , pro-inflammatory elements , Immunosuppression , Rehmannia glutinosa Residue , Poria cocos Bark
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|